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Gastric cancer biomarkers

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    The determination of serum tumor markers plays an important role in screening for a disease, in diagnosing a disease, in determining the prognosis of a disease and in assessing the activity and complications gastric cancer biomarkers the disease, in monitoring the therapy in the tumor prevention stage, as well as for the follow-up examination during therapy, in the management of the illness for relapse detection for the patients with certain tumor-associated disease.

    Thus, the detection of tumor marker levels in human serum is absolutely necessary in clinical assay.

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    The first amperometric immunosensor for tumor markers was reported in Aizawa et al. Monoclonal anti-hCG was immobilized on an amperometric oxygen electrode.

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    Catalase-labeled-hCG and hCG in the sample competed for binding sites of immobilized anti-hCG on the electrode surface. After a washing step to remove nonspecifically bound hCG, the sensor was then reacted with the substrates.

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    • Ana-Maria Enciu - Referințe bibliografice Google Academic

    Membrane-bound catalase generated oxygen that was sensed by the oxygen electrode. Since then different other electrochemical immunosensors for the quantification of tumors markers have been developed, as for example: immunosensor for cancer biomarker prostate specific antigen PSA with a detection limit of 0.

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    The MUC1 gene encodes a type-I transmembrane glycoprotein that is expressed on the apical surface of most simple epithelia, including mammary gland, female reproductive tract, papilomul mâncărime la ochi, kidney, stomach, gall bladder, and pancreas as well as some non-epithelial cell types.

    Recent immunological studies suggest that MUC1 is a potential marker and a prognosis factor in diagnosis of ovarian cancer and endometriosis. Gastric cancer biomarkers research project proposed the elaboration of a novel series of immunosensors based on MUC1 and tumor MUC1 proteins, which can be a specific and sensitive alternative to currently more or less invasive, immunohistochemical methods actually used.

    gastric cancer biomarkers

    Once the tumor proteins in blood successfully detected, will be followed by the design and construction of a noninvasive, specific and sensitive diagnostic device for biological fluids.